Now, you can get year-tround protection against fleas and five kinds of ticks, total roundworm and hookworm control, and heartworm prevention with just one tasty, chewable dose a month. Sarolaner inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor, and works at the. This includes all three doses of the medication, which are given at 2-week intervals. 6 and 11 pounds 1. Simparica Trio Results Value: Simparica Trio Both preventatives are have six weight brackets to choose from: 2. SIMPARICA can be offered by hand, in the food, or administered like other tablet medications. 99. The medication is available in different dosage strengths to suit. Simparica Trio is an all-in-one parasitic preventative. This comprehensive guide will. The brown box Simparica Chewable Tablets for Dogs, 88. 011 mg/lb (24 µg/kg) moxidectin, and 2. A 6-month supply of chewable Simparica tablets ranges in price from $80 to $100 on average. It can also prevent new infestations of. 27 for 6 doses. Simparica Trio is somewhat more expensive than Bravecto, but it is well worth the extra money if you value the added convenience of protection against intestinal worms and heartworm disease. 27 or 16. Remember, Simparica Trio prevents heartworm disease but is not effective against adult D. There are some differences between these two options that should be considered before you make your decision. Q. 69. Simparica Trio contains a specially optimised trio of ingredients for proven efficacy including the ingredient moxidectin, the same ingredient used by vets to protect against deadly heartworm disease. Simparica TRIO (sarolaner/moxidectin/pyrantel) is a flavored chewable tablet for administration to dogs 8 weeks of age and older. Currently, these are Nexgard®, Bravecto® and Simparica®, and Credelio®. 5–5 kg 10 for dogs >5–10 kg 20 for dogs >10–20 kg 40Simparica TRIO® Chewable Tablets for Dogs 12mg (5kg-10kg) SRP £0. Simparica Trio starts killing fleas within 4 hours of administration, whereas, NexGard Spectra begins killing fleas within 6-8 hours of administration. Rated 4. Simparica Trio boasts a broader spectrum of protection, offering defense against both external and internal parasites. com. 1. Off-label, it is used to manage ear mite infestations, sarcoptic and demodectic mange. 3. K9 Advantix II Flea, Tick and Mosquito Prevention for Dogs, 6 Doses$91 now 16% off. Urban areas with dense pet populations can also propagate the spread of fleas and ticks. It is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis), and the treatment and control of tick infestations [Amblyomma americanum (Lone Star. Środek przeciwpasożytniczy ma słabo wyrażoną zdolność do kumulacji w organizmie, dlatego jego działanie utrzymuje się przez długi czas - do 35 dni. Simparica è vendibile esclusivamente previa ricetta medica, dunque NON è un farmaco di libera vendita. Food & Drink. The brown box Simparica Chewable Tablets for Dogs, 88. 1 to 22. £19. Sort by. Simparica Trio is particularly beneficial in regions with high prevalence of ticks, fleas, heartworm, and intestinal worms. 1 to 44 pounds, 44. Flea & Tick. Dogs weighing 5. Upto 55% Off On All Orders with Simparica Flea And Tick Chewable Promotional Code. 3676 out of 5 stars. The active ingredient in Simparica is known as sarolaner which used for inhibiting the neurotransmitter aminobutyric acid’s function, which is also known as GABA. $76 for 6. 011 mg/lb (24 µg/kg) moxidectin, and 2. Dogs and cats have a barrier that protects these. 1-88. Both products effectively kill adult fleas within just a short time after being given and last for a month. Simparica has not been evaluated in dogs that are pregnant, breeding or lactating. Nexgard : Boehringer Ingelheim. They know there's no time to waste when it comes to protecting our furry friends, so Simparica starts killing fleas and ticks within hours and keeps. I can feel her body trembling, and it. It contains three active ingredients —sarolaner, moxidectin, and pyrantel— that work together to prevent and treat flea and tick infestations. 2. 11. Small dog will take at least 5 tablet. Showing 12. Simparica Trio treats and protects against harmful parasites. While Simparica Trio is generally safe, some dogs may. SIMPARICA should not be used in dogs less than 6 months of age (see Animal Safety). What is Simparica Trio and what is it used for? Simparica Trio is a veterinary medicine used to treat dogs with flea or tick infe stations and roundworm or hookworm infections in the gut. 91 mg/lb (2 mg/kg). Simparica Chewable Tablet for Dogs 44. . The material contained within this website is intended to be viewed by UK practising veterinary surgeons only. 8-5. 1x 10mg tablet for 5. 1 to 88 pounds, or 88. See full Prescribing Information. SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. Medicare. The FDA has approved this product for use in dogs between 5. Simparica:. How this medicine should be used: Simparica should be administered orally, once every month, at the minimum dosage of 0. Available by prescription, it works quickly and provides an entire month of protection. The following side effects have been reported with the use of Simparica Trio® : vomiting, diarrhea, lethargy, and inappetance. Tax included. This medication contains a powerful Sarolaner, a powerful isoxasoline drug, which the FDA warns can produce serious. Sarolaner is a member of the isoxazoline class. Heartgard, on the other hand, is a veteran in the field, predominantly known for its effectiveness against. Proven persistent protection against. Como tratar intoxicação de ivermectina em gatos? O tratamento das intoxicações causadas pela ivermectina requer suporte e fluidoterapia intensa com cristalóides. Simparica Trio is the first product to combine sarolaner, moxidectin and pyrantel in one convenient dose. Simparica has been safely used in dogs treated with commonly prescribed vaccines, parasiticides and other medications. Flea and tick worm infestation can be irritating for your dog and you as a dog owner. More Choices Available. 1x 20mg tablet for 11. 2% effective even on the 35th day of treatment 1. com will no longer accept new orders. How long does Simparica protection last? Simparica is a monthly chewable whose 35-day protection period begins in hours. It is exclusively indicated when use against ticks or fleas, and gastrointestinal nematodes are indicated at the same time. Dogs weighing between 2. 1-132 lbs Count: 3 Chewable. Simparica vs. There are very few side effects when the drug is given at the usual dose. By consulting with your veterinarian, following dosage instructions, monitoring your dog, considering alternatives, and reporting. March 2016 saw the addition of Simparica, yet another so-called Isoxazoline flea and tick “remedy”… and already several dogs have been adversely affected by this new drug. 5 lbs, (Yellow Box) By Simparica 15 Ratings Prescription Item Pet Weight: 2. Simparica Trio is FDA. Is Simparica Safe for Dogs? Coming from the house of Zoetis, Simparica is an efficient flea and tick treatment providing a gamut of benefits to both dogs and pet parents. com. The active substance – sarolaner in Simparica is an effective an insecticide and acaricide that belongs to the group of isoxazoline. Simparica uses a trio of Saroloner, Moxidectin, and Pyrantel to combat fleas and ticks, along with the parasites listed above. 1K+ bought in past month. suppl. Both Capstar and Simparica have their unique strengths and serve different purposes. Free shipping and price match available. Simparica TRIO® Chewable Tablets for Dogs 72mg (40kg-60kg) SRP £0. Original review Jun 21, 2022. 00) This is day 2 since administering this, yet both dogs are still miserable , itching and scratching. 1-88 lbs, (Green Box), 6 Chewable Tablets (6-mos. Para fazer efeito, a dose deve ser dada de acordo com o peso do animal. Say goodbye to pesky, persistent pests and hello to Simparica. She also has the shakes from time to time. $63. Simparica Cost. Simparica TRIO is a tasty monthly chew that provides triple protection against a trio of the biggest threats facing our dogs. Simparica kills adult fleas, and is indicated for the treatment and prevention of flea infestations, and the treatment and control of tick infestations from lonenstar ticks, Gulf Coast ticks, American dog tick, black-legged ticks and brown dog ticks for one month in dogs 6 months of age or older and weighing at least 2. Rated 5 out of 5 by 13 reviewers. Simparica has been safely used in dogs treated with commonly prescribed vaccines, parasiticides and other medications. NexGard tablets kill fleas within 4 hours and ticks in about 24 hours. 4,200. Simparica TRIO with a detailed product breakdown. Simparica tablets are chewable and palatable and readily consumed by dogs when offered by the owner. Simparica prevents and treats infestations with fleas and ticks. Simparica is a monthly flea and ticks tablet for dogs that provides broad-spectrum protection for 35 days. Simparica Trio protects dogs from heartworms and other worms, plus fleas and ticks, all in one chewable pill. Type: Over-the-counter, topical | Active ingredients: Imidacloprid, permethrin, and pyriproxyfen. It is a monthly treatment that effectively prevents flea and tick infestations. Simparica Trio and Nexgard are highly effective against fleas and ticks. Simparica Trio® works to prevent heartworm disease, treat and prevent flea infestations, treat and control tick infestations, and treat and control roundworms and hookworms. Buy Simparica Chewable Tablet for Dogs, 22. It is a convenient, reliable way to protect your pet from fleas and ticks, as well as tick-borne illnesses. acari dell'orecchio. 12 mg/25 mg. When comparing NexGard to Simparica Gulf Coast ticks could be a deciding factor. Simparica Chewable Tablets for Dogs. Closure of Site. Simparica is highly palatable and is readily consumed by dogs when offered as treat, however tablets may also be given with a small amount of food or administered directly into the mouth; For dogs over 60 kg, administer an appropriate combination of chewable tablets to achieve the recommended dose rate of 2 to 4 mg/kg body weight. Simparica Trio® is intended for dogs and puppies weighing more than 2. Simparica does cost more per box, but the weekly price differences are between $. After 1 emergency vet visit and a number of consultations with our primary care vet, we took him off simparica. Simparica Trio is a veterinary medicine used to treat dogs with flea or tick infestations and roundworm or hookworm infections in the gut. SIMPARICA ® (sarolaner) is a flavoured chewable tablet containing 5, 10, 20, 40, 80, or 120 mg of sarolaner, an ectoparasiticide intended for administration to dogs according to their weight. Simparica Trio Chewables for dogs is a remarkable broad-spectrum parasite treatment. Simparica should be administered at a dose of 2-4 mg/kg bodyweight in accordance with the following table: Use appropriate combination of available strengths to achieve the recommended dose of 2–4 mg/kg. Sarolaner inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor, and works at the neuromuscular. 2-2. Analyzing performance and cavitation for rotodynamics pumps, turbines and compressors. Simparica Trio is the first and only product that combines sarolaner, moxidectin, and pyrantel in one simple-to-give chewable-for protection against heartworm disease, ticks & fleas, roundworms & hookworms. Simparica 1 - 6 of 6 Results Sort Filter More Choices Available Simparica Chewable Tablet for Dogs, 44. 1-22 lbs, (Orange Box), 12 Chewable Tablets (12-mos. Simparica for dogs is a medication designed to prevent this. 40/Gram) $17. supply) at Chewy. So, fill it out. Simparica Trio might be more expensive when the two are side by side, but ultimately it is the better value. Simparica for the Control of Dog Flea Infestations. Starting 9/1/2023, WalmartPetRx. It contains three active ingredients: sarolaner, moxidectin, and pyrantel, with sarolaner being potentially. Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes to ensure that part of the dose is not lost or refused. If the tablet is not taken up. Trifexis contains two active ingredients - Spinosad and Milbemycin Oxime. However, for dogs with a known history of seizures or other neurological problems, the use of Simparica Trio should be carefully evaluated. It is indicated for the effective control of fleas and ticks. 01% of dogs taking this medication have experienced any neurologic side effects. It's a tasty tablet. However, like any medication, it’s essential to use it correctly and monitor your pet for any potential side effects. 10%. 8 pounds at a minimum age of 8 weeks, while Sentinel Spectrum can be used safely on puppies starting at 6 weeks old and 2 pounds in weight. With three active ingredients designed for defense, Simparica Trio keeps dogs protected from heartworm disease,. Simparica - a brand by Zoetis exclusively brings oral flea and tick treatment for dogs. Consistency is key to maintaining a flea and tick-free environment. Which means you can be confident knowing between each. Simparica trio is a de-worming medication. For example, some pet parents may choose Trifexis over Simparica Trio for its lower price. ; It can eliminate as many as five tick species: gulf coast. Purchased in Sept 2021 for $53. The main goal of this medication, according to the FDA, is; Simparica Trio is a once-a-month, easy-to-give chewable that helps simplify protecting your pet every month. 4. The range of Simparica includes Simparica Flea and Tick Chews and Simparica Trio Flea, Tick, Worm and Heartworm Chews. FREE delivery on first-time orders. Simparica is a prescription chewable flea and tick medication for dogs. 12 mg/25. 06 mg/12. Simparica is a veterinary medicine used to treat infestations with ticks and fleas, demodectic and sarcoptic mange (skin infestations caused by two different types of mites) and ear mite infestations in dogs. He had been taking the it for about 2-3 months. Keep SIMPARICA in a secure location out of reach of dogs, cats and other animals to prevent accidental ingestion or overdose. com will shut down permanently. Need flea medicine for extra large dogs or small dogs? There are 6 different dosage options depending on your dog’s weight, ranging from 2. With three active ingredients designed for defense, Simparica Trio keeps dogs protected from heartworm disease, fleas & ticks, and roundworms & hookworms. Simparica Trio™ chewable tablets were well-accepted by dogs, with the majority of flavored chewable tablets (91. Simparica Trio is the first and only product that combines Sarolaner, Moxidectin and Pyrantel all in one treatment. Prices. You can ask your vet for a single dose to see if your dog will. 1 to 132 pounds, along with three options for the number of chewables to purchase at one time: three, six, or twelve. No. Simparica Trio Chewable Tablets are the first and only product which combines sarolaner, moxidectic and pryrantal in one monthly treatment to protect against flea and tick infestations, aswell as controlling roundworms and hookworms. Simparica Trio is sarolaner, moxidectin, and pyrantel in a chewable once-a-month tablet with dosages based on the dog's size. at. $27. 2 mg/kg)Simparica Trio is a once-a-month, easy-to-give chewable that helps simplify protecting your pet every month. 2 mg/kg) sarolaner, 0. Drug Information. The most frequently reported adverse. Each tablet is formulated to provide a minimum sarolaner dosage of 2 mg/kg (0. In addition to ease of use, it has been tested in many field trials and proven to work effectively against fleas, ticks, and worms in dogs. Interceptor Plus boasts a savory chicken flavor, while Simparica Trio offers a tasty beef flavor. It starts to kill deer ticks within 8 hours, and fleas within 4 hours. Nesse vídeo eu falo sobre os comprimidos mastigáveis Bravecto, Simparic e Nexgardz digo se eles realmente acabam com pulgas e carrapatos em cachorros, coment. These flea & tick chewable tablets for dogs are proven to provide. This is especially true of tick control. 00, I received a $20. Compare Simparica vs. 0 lbs should be. The potent chewable tablet kills adult fleas and offers protection against flea. Other tick species, such as Rhipicephalus sanguineus (sensu. After Simparica is given its activity against ticks and fleas lasts for at least 5 weeks. 99 Chewy Price. Online Sales 7. Simparica Trio has some essential qualities that make it so effective and popular among dog owners. The treatment lasts for 35 days so monthly use is sufficient to keep your dog. See full Prescribing Information. You may purchase prescriptions and refills from the pharmacy of your choice. Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes to ensure that part of the dose is. Precautions. Existing customers will still be able to view the site for information regarding their pharmacy records and order history. Simparica Chewable Tablets for Dogs- 22-44lbs (40mg) Blue (Sarolaner 40 mg) DESCRIPTION:Simparica is a fast-acting oral flea and tick preventative that begins killing fleas and ticks within hours of administration and remains effective for one month to prevent re-infestations. 0 mg) IndicationsSimparica is a flea treatment with sarolaner as its active ingredient, for dogs and puppies six months and older, and weighing more than 2. 54 milligrams of sarolaner, 0. While Capstar provides rapid relief from severe infestations, Simparica acts as a long-term protective shield against fleas and ticks. Since coming to the attention of Zoetis, the company is. 8 pounds and greater. To make dosing easy, it's available for dogs in six sizes based on body weight range: Gold: 2. Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes to ensure that part of the dose is. Simparica Chewable Tablets for Dogs are an effective, safe medicine used to protect dogs against fleas and ticks. J – July 27, 2022 – Zoetis is aware of a social media post originating on Facebook that references Simparica Trio® (sarolaner, moxidectin, and pyrantel chewable tablets,), a potential neurologic adverse event and the subsequent euthanasia of a dog in the U. The revolutionary chewable tablet – Simparica is highly effective in eliminating fleas and various types of ticks. Simparica Chewable Tablets are fast acting, safe monthly flea and tick protection for dogs. Sarolaner, sold under the brand name Simparica, is an ectoparasiticide veterinary medication for the treatment of flea and tick infestations in dogs. 2%. The chews also help in eliminating fleas and ticks including five tick types: Black-legged ‘deer’ ticks, American dog ticks, Gulf Coast ticks,. 91 mg/lb (2 mg/kg) sarolaner. Simparica Trio should be administered at a dose of 1. ConclusionsSimparica may cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures. The cost of Simparica varies depending on the dosage strength and type. 5. Each tablet is formulated to provide a minimum sarolaner dosage of 2 mg/kg (0. Simparica 80mg Chewable Tablets are tasty chewable tablets used to treat tick, flea and sarcoptic mange infestations in dogs weighing >20kg - 40kg for up to 5 weeks. Nexgard Spectra. The medication is convenient to use and typically administered monthly. 54 mg/lb (1. 25 kg. Sarolaner is a class of neurotoxin. 25% Off Order Over $99 with Simparica Amazon Promotional Code. The green box Simparica Chewable Tablets for Dogs, 44. Moreover, the FDA entreats the manufacturers of these products –. 6 to 11 pounds. 27 mg/lb (5 mg/kg) pyrantel (as. However, it is essential for pet parents to know that Simaprica Trio is an all-on-one monthly chewable that protect dogs against five types of ticks, fleas, roundworms, hookworms. Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes to ensure that. 2% effectiveness, proving its worth as a reliable preventive medication. 1-132 lbs is $99. Simparica can be offered by hand, in the food, or administered like other tablet medications. 61 per dose. It's a tasty tablet that works to shield your pet for a full 35 days, killing fleas before they can lay eggs. I gave my two dogs Simparica Trio on 5/17/22 per the vet. 99, which is -12% off the average retail price of $161. Average Discounts 15% OFF. 8 pounds or more, tab Simparica kills adult fleas and is recommended for the treatment and control of tick infestations caused by Amblyomma maculatum, Dermacentor variabilis, Ixodes scapularis, and. 00. SIMPARICA ® (sarolaner) is a flavoured chewable tablet containing 5, 10, 20, 40, 80, or 120 mg of sarolaner, an ectoparasiticide intended for administration to dogs according to their weight. 99. Product Description. He had been taking the it for about 2-3 months. 9%) voluntarily consumed by free choice without, or when offered in food. In a study with 98 dogs with demodectic mange, 63 dogs were treated with Simparica monthly for up to six months and 35 dogs received moxidectin/imidacloprid. 00 discount for agreeing to autoship. 00 – $ 302. SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. Simparica Trio kills fleas and paralysis ticks as well as provides persistent protection against flea and tick for five weeks. Bravecto lasts for 12 weeks as opposed to 35 days like Simparica. Simparica may cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures. The box has the following precaution: Sarolaner, one of the ingredients in Simparica Trio, is a member of the isoxazoline class. Heartgard uses Ivermectin to prevent heartworm disease, while Nexgard uses Afoxolaner to tackle fleas and ticks. 4. Simparica Trio also prevents heartworms and keeps hookworms and roundworms from harming your pup. 3–2. As per the vet, Simparica is an excellent flea and tick product that is available in oral form. Fortunately for conscientious dog moms and dads, Simparica offers a once-a-month chewable treatment that is FDA-approved and safe for Fido, taking the guesswork out of fighting fleas and ticks. The most frequently reported adverse. The mint box Simparica Chewable Tablets for Dogs, 22. As pet parents, we strive to ensure our furry companions stay healthy and protected from harmful parasites. Simparica Trio for Dogs is a highly effective oral treatment for controlling internal and external parasites in dogs. 1 to 132 pounds, along with three options for the number of chewables to purchase at one time: three, six,. Simparica Trio for Dogs. Or fastest delivery Wed, Nov 8. Tablets can be administered with or without food. Killing fleas before they can lay eggs, kills 5 types of ticks, treats and prevent flea infestations and treats and control roundworms and hookworms, with one monthly dose. Simparica and Nexgard both have efficacy against fleas for 35 days after dosing, however, Nexgard only has effective action against ticks for 4 weeks, whereas Simparica maintains. Simparica kills 4 types of ticks and adult as well as larvae life stages of fleas. 0 lbs should be given one 10 mg Simparica chewable tablet monthly. SIMPARICA TRIO contains three active pharmaceutical ingredients, sarolaner, moxidectin, and pyrantel pamoate. 5 mg. More than 98% efficacy in killing existing tick infestations in 48 hours. 5 lbs should be given one 5 mg Simparica chewable tablet monthly. 10. 5. Simparica Trio starts killing fleas within 4 hours and has a 100% effectiveness rate within 8 hours for the entire month. It is the most convenient flea and tick protection product on the market. 6-11 lbs 11. Simparica Trio™. Simparica may cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures. Starting 9/1/2023, WalmartPetRx. Simparica Trio is a once-monthly chewable tablet that can treat existing flea and tick infestations and help prevent fleas, ticks, heartworm, roundworm and hookworm. It is notably a medication for protection from Gulf coast. Simparica works faster on ticks, killing them within 12 hours of jumping on and feeding. $60. Simparica Trio boasts a broader spectrum of protection, offering defense against both external and internal parasites. The U. During clinical field trials, no interactions between Simparica chewable tablets for dogs and routinely used veterinary medicinal products were observed. 67 for 6 doses. 8. It contains sarolaner, which kills fleas and ticks, moxidectin, which helps prevent heartworm disease and pyrantel, which treats and controls roundworm and hookworm. Simparica has been safely used in dogs treated with commonly prescribed vaccines, parasiticides and other medications. In isolated cases, however, dogs displayed. 4. Simparica may cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures. Moreover, they can both be used safely on pups; Simparica Trio can be administered to puppies weighing 2. (Originally $63. 91 for 3 doses or $95. Simparica TRIO is safe to use in dogs from 8 weeks of age and as little as 2. If a dose is missed, administer SIMPARICA and resume a monthly dosing. After being ingested by a dog, sarolaner is distributed throughout the body. Simparica's active ingredient, Sarolaner, begins to kill fleas within 3 hours and ticks within 8 hours. Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes to ensure that part of the dose is not lost or refused. Simparica Chewable Tablet for Dogs, 88. 8 pounds. With three active ingredients designed for defense, Simparica Trio keeps dogs protected from heartworm disease, fleas & ticks, and roundworms & hookworms. This once-a-month tablet gives you an easy, reliable way to protect your dog from fleas and ticks. Simparica jest skuteczną ochroną zwierząt domowych przed ektopasożytami, ponieważ pchły w kontakcie giną przed złożeniem jaj, co oznacza, że ryzyko ich rozmnażania jest wykluczone. Administered as an easy once-a-month chewable tablet, Simparica provides continuous coverage for 35 days. Simparica has not been evaluated in dogs that are pregnant, breeding or lactating. Simparica 120 mg chewable tablets for dogs >40–60 kg . Nesse vídeo eu falo sobre os comprimidos mastigáveis Bravecto, Simparic e Nexgardz digo se eles realmente acabam com pulgas e carrapatos em cachorros, coment. Simparica is the ONLY monthly tick and flea chewable approved to kill 5 types of ticks. 6% reduction in adult fleas within 14 days after treatment and reached 100% on Day 60. Zoetis (Simparica, Revolution Plus): 888-963-8471; If you prefer to report directly to the FDA, or want additional information about adverse drug experience reporting for animal drugs,. 5 pounds, 5. One chewable tablet provides month-long protection for all dogs over 8 weeks old and weighing 2. Comfortis is an excellent choice for cats and young puppies, but Simparica is slightly more effective. . Some mild simparica side-effects usually disappear within 48 hours without veterinary intervention, while severe ones may take days to weeks.